منابع مشابه
Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling.
Mitochondria generate second messengers, such as H2O2, that are involved in the redox regulation of cell signalling and their function is regulated by several cytosolic signalling pathways. IIS [insulin/IGF1 (insulin-like growth factor 1) signalling] in the brain proceeds mainly through the PI3K (phosphatidylinositol 3-kinase)-Akt (protein kinase B) pathway, which is involved in the regulation ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2020
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-020-05327-w